The observational studies [16, 20], that compared the macular OCT and OCTA measurements between intravitreal anti-VEGF and LPC in infants with TR-ROP were of critical overall risk of bias and in case a significant difference existed, IVB treatment showed lower mean foveal, parafoveal, perifoveal, and inner foveal thickness (Table 6). Here, VEGFA is linked to retinopathy of prematurity.