The finding of wild‐type p53 IHC staining, the usual pattern in HPV‐associated VSCC,15 in all tumors from Mozambique contrasts with the high proportion of VSCC from Spain with an abnormal p53 IHC staining, the commonest IHC staining in HPV‐independent carcinomas.15, 28. This evidence concerns the gene TP53 and carcinoma.