Although the roles of LPA in immune response and inflammation depend on the LPA receptors, considering that the levels of PC with less saturated acyl chains increased while the levels of PC with polysaturated acyl chains decreased, especially in subjects with severe COVID‐19 and the fact that polyunsaturated LPA is biased toward anti‐inflammatory LPA3,44, 45 these modulations might result in the overreaction of the immune response. Here, LPAR3 is linked to COVID-19.