Finally, IACS‐010759 also suppressed proliferation in Richter‐transformed CLL cells, which show high expression of OxPhos and MYC target genes [96]: it is tempting to speculate that venetoclax, S63845 or other BH3‐mimetic compounds may provide cooperative activity also in this context. The gene discussed is MYC; the disease is B-cell chronic lymphocytic leukemia.