MYC and acute myeloid leukemia: JQ1, a small molecule inhibitor of BET proteins, suppressed MYC expression in preclinical models of multiple myeloma (MM) and AML, effectively halting cancer growth in vitro and in vivo [170, 171], although these and other studies indicated that BRD4 inhibition has multiple consequences beyond MYC inhibition [172, 173, 174].