Indeed, activation of genes involved in ribosome biogenesis and protein synthesis are among the most conserved activities of MYC, consistent with its central role in cell growth and proliferation [255], and murine MYC‐driven lymphomas proved to be highly sensitive to the impairment in protein synthesis consequent to reduced ribosome biogenesis, either by knocking out a ribosomal protein [256] or by pharmacological inhibition of RNA Polymerase I – and thus of rRNA synthesis [257]. The gene discussed is MYC; the disease is lymphoma.