CASP1 and infection: To investigate whether inflammasome activation affects type I IFN response during PRU infection, we compared IFN-I production between WT and Casp1/11−/− mice infected with PRU and found that the IFN-β expression in splenocytes was enhanced when caspase-1/11 was deficient, along with a marked increase in TBK1 phosphorylation (Fig. 4A and B).