During malaria, AIM2 and NLRP3-induced CASP1-dependent inflammasome signaling induces the release of IL-1β in pDCs and activates IL-1 signaling, which induces negative regulator SOCS1 in a MyD88-TRAF3-IRF3-dependent manner and inhibits MyD88-IRF7-dependent type I IFN signaling in pDCs (47, 59). The gene discussed is IRF3; the disease is malaria.