To this end, we first compared inflammasome activation in WT and Casp1/11−/− mice after PRU infection and found that cleavage of IL-1β was completely abolished in Casp1/11−/− splenocytes at 24 hpi (Fig. 2A), suggesting that downstream molecule caspase-1/11 is essential for inflammasome activation induced by T. gondii. The gene discussed is IL1B; the disease is infection.