Results: At the false discovery rate (FDR) <0.05 and fold change (FC) ≥1.5, a total of 625 differentially expressed genes (DEGs) were identified between lymphoma and non‐lymphoma samples, including 347 up‐regulated DEGs such as SLC38A11, SCN3A, ZIC5, etc. and 278 down‐regulated DEGs such as LOC475937, CSMD1, KRT14, etc. Especially, the pathway of PI3K‐Akt signaling, which was directly related to the lymphoma, was enriched in KEGG analysis. This evidence concerns the gene ZIC5 and lymphoma.