Background: Phenylbutazone is the most prescribed compound for the management of hyperinsulinemia‐associated laminitis (HAL); however, it has been shown in people that, non‐steroidal anti‐inflammatory drugs (NSAIDs) increased insulin secretion suggesting that phenylbutazone administration could result in hyperinsulinemia and exacerbate HAL. The gene discussed is INS; the disease is hyperinsulinism.