Follow-up studies using these tools should unravel with more detail the molecular mechanisms mediated by Tns3 not only in iOLs during developmental myelination but also in pathological contexts such as preterm birth dysmyelination, adult demyelination in MS and glioblastoma, this last one recently associated with reduced levels of Tns3 (Chen et al., 2017). Here, TNS3 is linked to glioblastoma.