Due to our observed preferential sorting of miR-223 into mouse DC-derived exosomes and the alterations to RAB27A and miRNA levels, we also determined if the known miR-223 exosome sorting protein, Y-box binding protein 1 (YBX1), as well as other known RBPs, were altered in patients with IBD (46, 47). This evidence concerns the gene YBX1 and inflammatory bowel disease.