We also assessed the response of these CD11c-Rab27a cKO and floxed mice to the αIL-10R mAb model of IBD and saw a phenocopy of the histological changes seen in Vav-Rab27A cKO mice challenged with this same model (Figure 3, K and L), including increased epithelial crypt depth and total number of inflammatory aggregates in Vav-Rab27A cKO mice (Figure 3M). Here, VAV1 is linked to inflammatory bowel disease.