ST3GAL3 is expressed in a variety of tissues, including neurons, and encodes a membrane protein (ST3Gal III) that adds sialic acid to the end of glycolipids or glycoproteins, a process that has an important impact on brain function, and St3gal3 single gene deletion mice have reduced motor coordination, cognitive impairment and behavioral hyperactivity (70, 71). This evidence concerns the gene ST3GAL3 and Cognitive impairment.