TACE causes the hypoxic microenvironment of the tumor, and researchers have shown that the expression of HIF-1α is significantly increased after TACE and is related to the poor prognosis of TACE [8, 9], so the current research on TACE nonresponse mainly focuses on the abnormal activation of the HIF-1 signaling pathway. The gene discussed is HIF1A; the disease is neoplasm.