This phenomenon is greatly enhanced both in AD mouse model and human LOAD cases, where Reelin deposits are co-localized with Aβ plaques, fibrillary tangles and correlate with cognitive deficits showing a distinct spatial and temporal function of Reelin in AD pathogenesis (Knuesel et al., 2009; Ramsden et al., 2022). The gene discussed is RELN; the disease is Cognitive impairment.