PPARGC1A and lymphoma: The overexpression of Sirt1 in diffuse large B-cell lymphoma (DLBCL) leads to the inhibition of PGC-1α protein expression, which affects mitochondrial synthesis (57), the PGC-1α/NRF1/TFAM pathway is inhibited and mitochondrial biogenesis is impaired in RA, which can explains the reasion why RA patients are more susceptible to lymphoma in some degree (40).