2-DG, a non-competitive inhibitor of HKs, restores mitochondrial homeostatic imbalances by reversing lipopolysaccharide-induced glycolytic activity, thereby inhibiting the expression of RA inflammatory cytokines, IL-1β and IL-6, and matrix metalloproteinase (MMP-1, MMP-3) (148). This evidence concerns the gene MMP1 and rheumatoid arthritis.