The overexpression of Sirt1 in diffuse large B-cell lymphoma (DLBCL) leads to the inhibition of PGC-1α protein expression, which affects mitochondrial synthesis (57), the PGC-1α/NRF1/TFAM pathway is inhibited and mitochondrial biogenesis is impaired in RA, which can explains the reasion why RA patients are more susceptible to lymphoma in some degree (40). The gene discussed is SIRT1; the disease is diffuse large B-cell lymphoma.