SIRT3, SIRT4, and SIRT5 genes and 8-hydroxy-2 deoxyguanosine (8-OHdG) levels were found to be significantly upregulated in synovial tissues of patient with RA, suggesting the key role of SIRTs and oxidative stress in the development of RA (50). Here, SIRT5 is linked to rheumatoid arthritis.