Meanwhile, LCA induces expression of uPAR and increases cell invasiveness via activation of ERK1/2 MAPK and AP-1 pathway in HT29 and SW620 cells (107) and inactivation of STAT3 and Src/EGFR pathways in HCT116 cells (92, 108, 109). Here, STAT3 is linked to Leber congenital amaurosis.