In contrast, LCA has been reported to promote CRC via promoting expression of MMP-2 in CaCo-2 cells (91), interleukin (IL)-8 in HCT116 cells (92), ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily G member 2 (ABCG2) in HCoEpiC cells (73), and miR-21, and inhibition of PTEN in HCT116 cells (93). Here, MMP2 is linked to Leber congenital amaurosis.