SIGLEC1 and infection: Given the assumption that CD169 is representing an important immunoregulatory player in the early stages of infection and disease progression, implications of loss-of-function phenotypic variants have demonstrated the course of infection in null individuals; Martinez-Picado et al. investigated a large cohort of HIV-infected individuals comprising of two homozygous and 97 heterozygous individuals expressing a specific stop-codon variant (Glu88Ter) in the CD169 gene (40).