Both the mislocalization and downregulation of Dlg-1, Scribble, and Lgl1 proteins seemed to be correlated to tumor progression in the RPE, due to their role in the onset of epithelial-to-mesenchymal transition (EMT), which was later found to be a common event in more aggressive human tumors (Gardiol et al., 2006; Humbert et al., 2008; Pearson et al., 2011; Elsum et al., 2012; Stephens et al., 2018), which also occurs in age-related macular degeneration (AMD) development (Goldberg et al., 2018). This evidence concerns the gene DLG1 and age-related macular degeneration.