Our confocal microscopy analysis confirmed previous evidence reviewed by Oakley and Cidlowski (2013) showing that GR was localized in cardiomyocytes, The deficiency in cardiomyocyte glucocorticoid signaling leads to spontaneous cardiac hypertrophy, heart failure, and death, revealing a mandatory role for GR in maintaining normal cardiovascular function (Oakley and Cidlowski, 2013). The gene discussed is NR3C1; the disease is heart failure.