TNF and obesity due to melanocortin 4 receptor deficiency: It could be inferred that the levels of TNF- α, IL6, and leptin increased and that of IL 10 decreased in the HFD/STZ/HYX and HFD/STZ treatments in males, which showed a significant effect of HYX, diabetes, and obesity when combined partially or entirely with each other or anti/pro inflammatory cytokines in male rats.