This study demonstrated that the combination of obesity, diabetes, and HYX was associated with the development of an inflammatory response at the mRNA and protein levels in both male and female rats; however, in male rats, there was a significant increase in the levels of TNF- α and IL6, and a significant decrease in IL10 compared with those in female rats. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.