As mentioned above, EFT promotes the occurrence of atrial fibrosis and increases AF burden through direct infiltration, secretion of adipocytokines, induction of inflammatory responses, etc. In addition, previous research has shown that resistin (an adipocytokine) and high-sensitivity c-reactive protein (an indicator of inflammation) are higher in patients with AF recurrence after catheter ablation [40, 41]. Here, RETN is linked to atrial fibrillation.