Expectedly, after 72 h of transfection, the protein levels of JMJD3 and HPK1 (Figures 4(a) and 4(b)) and the enrichments of JMJD3 (Figure 4(c)) and H3K4me3 (Figure 4(e)) at the HPK1 promoter all elevated greatly in SLE Tfh cells transfected with the JMJD3-overexpressing plasmid. The gene discussed is MAP4K1; the disease is systemic lupus erythematosus.