Expectedly, after 72 h of transfection, the protein levels of JMJD3 and HPK1 (Figures 4(a) and 4(b)) and the enrichments of JMJD3 (Figure 4(c)) and H3K4me3 (Figure 4(e)) at the HPK1 promoter all elevated greatly in SLE Tfh cells transfected with the JMJD3-overexpressing plasmid. This evidence concerns the gene KDM6B and systemic lupus erythematosus.