The results showed that H3K4me3 (Figure 5(a)) and MLL1 (Figure 5(b)) enrichments at the promoter in Tfh cells of the SLE group were reduced compared with those in the control group, and JMJD3 binding was positively correlated with H3K4me3 (Figure 5(c)) and MLL1 (Figure 5(d)) levels in Tfh cells from the SLE group. The gene discussed is KDM6B; the disease is systemic lupus erythematosus.