It has been confirmed that Tfh cells account for a significantly higher proportion in peripheral blood circulation of SLE patients, and they are positively correlated with SLE disease activity index (SLEDAI), antinuclear antibody (ANA), and anti-double stranded DNA (dsDNA) antibody levels in serum and are negatively correlated with complement C3 concentration [7, 8]. Here, C3 is linked to systemic lupus erythematosus.