KDM6B and systemic lupus erythematosus: It was also revealed that the JMJD3 binding was negatively correlated with H3K27me3 enrichment at the HPK1 promoter in Tfh cells of the SLE group (Figure 2(d)), while it was positively correlated with the mRNA (Figure 2(e)) and protein (Figure 2(f)) levels of HPK1.