In order to explore the cause of the increased H3K27me3 enrichment at the HPK1 promoter in SLE Tfh cells, the levels of EZH2, JMJD3, and UTX at the HPK1 promoter in Tfh cells from the SLE and control groups were measured by combining ChIP and qPCR assays. This evidence concerns the gene MAP4K1 and systemic lupus erythematosus.