IRF3 and asthma: Firstly, qPCR assay showed that asthma mice exhibited a substantial accumulation in lung tissue viral load, as well as a massive elevation in mRNA expression levels of TLR3, NF-κB, and IRF3, whereas CAD down-regulated lung tissue viral load, TLR3, NF-κB, and IRF3 levels in RSV-infected asthmatic mice (Figures 7(a)–7(b)).