Secondly, several studies have found that WHR was closely related to chronic inflammation and mitogen-activated protein kinase activity (19), and they could cause myocardial remodeling and fibrosis (41), resulting in myocardial injury, and systemic proinflammatory state caused by obesity could lead to inflammation of coronary microvascular endothelial cell, which in turn reduced the bioavailability of nitric oxide and protein kinase G activity, thereby accelerating myocardial injury (39). The gene discussed is WNK2; the disease is obesity due to melanocortin 4 receptor deficiency.