observed in a prospective cohort study of 1479 participants that higher WHR was independently associated not only with the prevalence of diabetes and the severity of heart failure, but also with higher mortality risk in women (hazard ratio: 2.23, 95% CI: 1.37-3.63, P < 0.05), but not in male participants, and they also found that WHR was positively correlated with inflammatory markers and mitogen-activated protein kinase cascade in female participants, whereas only positively correlated with platelet activity in men (19). This evidence concerns the gene WNK2 and heart failure.