BMP4 and type 2 diabetes mellitus: (36), 11 differentially expressed genes were substantially higher in the non-diabetic control group than in the T2DM group, and among these genes, BMP-4, which is significantly under-expressed in T2DM blood, is the most important gene regulating bone marrow mesenchymal stromal cells (MSCs) osteogenic differentiation based on gene ontology annotation and random forest analysis.