PRKAR1A and hyperthyroidism: We describe a man with subclinical hyperthyroidism and a <i>PRKAR1A</i> gene variant who was diagnosed with Carney complex (CNC), and we performed a systematic review of published studies to assess the association between <i>PRKAR1A</i> gene variants and the risk of subclinical hyperthyroidism.<h4>Design and methods</h4>The PubMed, EMBASE, OVID, Science Direct, and gray literature electronic databases were searched for articles published from January 2002 to May 2021 using predefined keywords and inclusion and exclusion criteria.