NFE2L2 and neoplasm: In the TRAMPC mouse model and in the TRAMPC1 PCa cells, expression of NRF2 is suppressed due to promoter methylation (S. Yu et al., 2010), which can be reversed by sulforaphane (Ferreira et al., 2018; C. Zhang et al., 2013), a synthetic curcumin analogue (Khor et al., 2011; W. Li et al., 2016), 3,3′-diindolylmethane (T. Y. Wu et al., 2013), and Indole-3-carbinol (T. Y. Wu et al., 2012) to enhance NRF2 expression and reduce PCa tumor size in TRAMPC PCa mice.