In addition to boosting insulin secretion and insulin-stimulated glucose uptake, HIIT also reverses hyperglycemia in an insulin-independent manner, involving contraction-mediated glucose uptake, increased GLUT-4 content, and improved muscle blood flow, all of which increase glucose delivery to active muscle (Little et al., 2010; Chavanelle et al., 2017; Dela et al., 2019). This evidence concerns the gene INS and Hyperglycemia.