The findings of Madsen et al. (2015) that 8 weeks of HIIT did not change insulin secretion in patients with T2D is consistent with our study where the DHIIT1:1 group did not change insulin levels (although there were improvements in FBS), suggesting that the HIIT1:1 protocol may reduce FBS in an independent-insulin manner (Cartee, 2015; Sylow et al., 2017). This evidence concerns the gene INS and type 2 diabetes mellitus.