In addition, the morbidity of severe EPI was 12% (95% CI: 7%–19%, I2 = 86.17%) in type 2 diabetes patients with higher insulin requirement (1 group), which was significantly higher than that in patients with lower insulin requirement (2 group) (2%, 95% CI: 0%–13%, I2 = 86.58%) (Supplementary Figure 2). Here, INS is linked to type 2 diabetes mellitus.