Restoring NRF2 activity in iPSC-derived MSCs from HGPS patient fibroblasts increased their viability, indicating that NRF2 activation maybe useful in counteracting the premature exhaustion of adult stem pools normally seen in HGPS patients (Halaschek-Wiener and Brooks-Wilson, 2007; Liu et al., 2011; Zhang et al., 2011). The gene discussed is NFE2L2; the disease is Hutchinson-Gilford progeria syndrome.