TNKS2 and cancer: Several DEcircRNAs between Landrace pigs in the LN and LL groups (such as novel_circ_001713, novel_circ_000707, and novel_circ_005275) were derived from cancer- and disease-related genes, such as TNKS2, KLF12, and BTAF1, which activate numerous signaling pathways involved in DNA damage, apoptosis promotion, and mitochondrial dysfunction caused by an insufficient oxygen supply (Adami et al., 2018; Vinchure et al., 2021).