The novel_circ_002672–ssc-miR-136-5p–SOCS4 axis between the TN and TL groups may have a vital role in a series of pathological changes, including thyroid carcinoma, lung squamous cell cancer, pentose and glucuronate interconversion, and ascorbate, aldarate, and retinol metabolism; it may also regulate the IKKβ/NF-κB/A20 pathway as a modulator of the inflammatory response (Deng et al., 2018; Xie et al., 2018; Gao R. Z. et al., 2019). The gene discussed is SOCS4; the disease is squamous cell lung carcinoma.