RRAGC and diffuse large B-cell lymphoma: Moreover, moderately activating mutations in RagC have been exclusively found in human follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) samples (Green et al., 2015; Okosun et al., 2016), while a mild inhibition of nutrient signaling to mTORC1 impairs the GC response (Ortega-Molina et al., 2021).