Previous studies have implicated tumor suppressor NDRG1 in mediating iron chelation mechanism of action through the inhibition as EGFR, TGF-β, and STAT3 (Le and Richardson, 2004; Lui et al., 2015b; Menezes et al., 2019; Yang et al., 2021). The gene discussed is NDRG1; the disease is neoplasm.