As MRE11 and NBS1 deficiencies sensitize human cancer cells to etoposide (Hoa et al., 2016), it is worth investigating combination with etoposide and the MRE11 endonuclease inhibitors (PFM 01 and 03) in cancer cell lines as well as tumor xenograft models with different MRE11 expressions. The gene discussed is MRE11; the disease is cancer.