ARRB1 and neoplasm: Moreover, ARRB1 plays an important role in tumor cell epithelial-to-mesenchymal transition (EMT) (Kong et al., 2018; Song et al., 2020; Song et al., 2021) and metabolic reprogramming (Mamouni et al., 2021), and also regulates important signaling pathways in tumors (Bagnato and Rosanò, 2019).