IL10 and myocardial infarction: For instance, platelet-derived growth factors as well as transforming growth factor-beta are involved in the negative inflammatory and fibrogenic response in the infarcted myocardium (Myocardial Remodeling, 2011; Dobaczewski et al., 2011) while IL-10 is a potent anti-inflammatory agent suppressing the synthesis of proinflammatory cytokines (Fiorentino et al., 1991), and activation of IGF-1 protects from the detrimental effects of myocardial infarction (Troncoso et al., 2014).