VEGFA and age-related macular degeneration: Intravitreal injection of anti-VEGF is widely used as the first-line drug in clinicfor the treatment of AMD because of its low visual impairment and few adverse effects, but there are still problems such as the need for repeated multiple treatments, the lack of response to treatment in some patients, and the increased risk of repeated intravitreal injection (Gale et al., 2003; Tavakoli et al., 2020; Wei et al., 2020).