ESR1 and pneumonia: HSP90AA1 is an inflammation-related protein that can be significantly upregulated with some inflammation-related genes in the inflammatory response [34, 35]; PTGS2 is involved in inflammation, immunity, and other processes [36, 37]; ESR1 is also involved in inflammation and immunity and is one of the key targets for the treatment of pneumonia [38, 39]; and MAPK14 is related to autophagy and plays an important role in immune response [40].