On this basis, the cardiac protection mechanism of WenXin KeLi improving CX43 expression and reducing the risk of arrhythmia after MI was further analyzed from the perspective of the PI3K-AKT-mTOR autophagy pathway, hoping to provide new experimental evidence for revealing the molecular mechanism of TCM in the prevention and treatment of arrhythmia after MI. The gene discussed is GJA1; the disease is Arrhythmia.