SOD1 and metabolic dysfunction-associated steatotic liver disease: In this study, we found that obvious lipid droplets appeared in the liver in NAFLD mice induced by HFD after 12 weeks and densely appeared after 24 weeks, accompanied by a significant increase of serum TC, TG, and LDL-C, hepatic AST, ALT, and MDA, and decrease of hepatic GSH and SOD.