HMOX1 and metabolic dysfunction-associated steatotic liver disease: TH increased the mRNA expression of hepatic TRX1, GCLC, and NQO1 (Figures 3J-L), decreased the protein expression of Keap1, and increased Nrf2, NQO1, and HO-1 of NAFLD mice (Figure 3M), indicating that TH activated Nrf2 pathway, inhibited oxidative stress, and protected against NAFLD.