Previous studies have confirmed that RANKL/OPG signaling, TNF and TNF receptor superfamily, and the NF-kB signaling pathway play important roles in osteomyelitis in S. aureus infection (Lio et al., 2012; Krauss et al., 2019), and other studies also demonstrated that curcumin can inhibit NF-κB signaling pathway (Mohankumar et al., 2015; Kao et al., 2016). The gene discussed is TNFSF11; the disease is osteomyelitis.