Recently, we demonstrated that an RGD fiber-modified OBP-301 variant (OBP-502) improves the anti-tumor efficacy of anti-PD-1 antibody in a syngeneic mouse model of colorectal and pancreatic cancer via induction of ICD and enhancement of CD8+ T cell tumor infiltration.11 Here, PDCD1 is linked to familial pancreatic carcinoma.