MT1-MMP can directly process ECM components and can also promote invasion through the activation of effector proteases.26 MMP2 is directly activated by MT1-MMP27; and MMP2 has been associated with poor GBM patient outcome.28 We found that, similarly to MT1-MMP, the expression of MMP2 increases with disease progression in both the Rembrandt (Figure 2D, left panel) and CGGA databases (Figure 2D, right panel). This evidence concerns the gene MMP2 and glioblastoma.