MMP14 and glioblastoma: MT1-MMP can directly process ECM components and can also promote invasion through the activation of effector proteases.26 MMP2 is directly activated by MT1-MMP27; and MMP2 has been associated with poor GBM patient outcome.28 We found that, similarly to MT1-MMP, the expression of MMP2 increases with disease progression in both the Rembrandt (Figure 2D, left panel) and CGGA databases (Figure 2D, right panel).