The time mice spent in the corner zone (Supplementary Figure 1C, p = 0.3481, t = 0.9555) or central zone (Supplementary Figure 1D, p = 0.2191, t = 1.259) in the open field test and the time mice spent in open arms (Supplementary Figure 1E, p = 0.2727, t = 1.121) or closed arms (Supplementary Figure 1F, p = 0.7198, t = 0.3657) in the elevated plus maze test showed that the anxiety levels in the MAD2B cKO group were comparable with those in the WT group. The gene discussed is MAD2L2; the disease is Anxiety.