Indeed, the overexpression of S100β has been found in the temporal lobe of fetuses with DS at 18–19 gestational weeks, neonates and infants (Griffin et al., 1989), in the frontal and temporal lobes of adults with DS (Jorgensen et al., 1990; Mito and Becker, 1993; Royston et al., 1999), and the cerebellum of middle-aged and old Ts1Cje mice, a DS model (Creaú et al., 2016). The gene discussed is S100B; the disease is Dravet syndrome.