THBS1 and Dravet syndrome: In agreement with these results, studies have demonstrated that deficits of thrombospondin-1 (TSP-1, an extracellular matrix component involved in cell–cell and cell–matrix communication) in DS astrocytes can cause the alterations of dendritic spines and synapses similar to those reported in DS neurons (Garcia et al., 2010; Torres et al., 2018).