As PrPc can interact with Aβ oligomers in AD pathology (Walsh et al., 2014a), the role of PrPc in cell-to-cell spreading of α-syn pathology and subsequent cognitive deficits have been explored (Esposito et al., 2007; Sousa et al., 2009; Brás et al., 2018). Here, PRNP is linked to Cognitive impairment.