In the context of AD, cofilin dephosphorylation occurs as a result of Aβ activation of the Cdc42 pathway leading to subsequent downregulation of RhoA and LIMK (Chen and Wang, 2015), while ATP depletion during oxidative stress promotes the ADP-bound actin state (Atkinson et al., 2004). This evidence concerns the gene RHOA and Alzheimer disease.