In addition, experiments have shown that minocycline regulates M1/M2 microglial polarization through the STAT1/STAT6 pathway, reduces the production of M1-like polarization genes and enhances the expression of M2-like polarization genes by regulating STAT1 and STAT6 signaling, thus achieving the treatment of ischemia (97). Here, STAT6 is linked to ischemia.