Furthermore, key epigenetic factors that may be possible targets in myeloma include proteins well-known to be crucial in myeloproliferative/myelodysplastic disorders such as IDH2, DNMT3A/B, MMSET (WHSC1/NSD2), SETD2 and the polycomb repressive complex 2 (PRC2) complex (EZH2/PHF19); nonetheless, they are also promising target in MM. This evidence concerns the gene NSD2 and plasma cell myeloma.