CD4+ T cells contain two diverse subsets of helper T cells, namely, Th1 cells, which produce TNF-α, IFN-γ, IL-2, and IL-12 to mediate antitumor effects, and Th2 cells, which generate IL-4 and IL-10 and foster tumor growth by suppressing the host immune system (49). This evidence concerns the gene CD4 and neoplasm.