Besides EDA-FN, three variables at diagnosis were significantly correlated with splenomegaly progression: WBC >12x109/L (HR = 3.73; 95% CI, 1.09-12.82; P=0.036), CD34+ blood cells > 50 x106/L (HR = 11.11; 95% CI, 1.95-58.82; P=0.006), and spleen size (HR = 1.03; 95% CI, 1.01-1.04; P=0.001). The gene discussed is FN1; the disease is Splenomegaly.