To explore whether GPC-3 has diagnostic accuracy and prognostic significance of HCC, we did a systematic review and meta-analysis.<h4>Method</h4>PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched with keywords "GPC-3" and "HCC" and their MeSH terms from inception to July 2022. The gene discussed is GPC3; the disease is hepatocellular carcinoma.