MDK and breast cancer: The following combination of biomarkers was identified for detection of BC in males: urine NSE, serum PAI-1/tPA, urine midkine, urine NGAL, urine MMP-9/TIMP-1 and serum prolactin (AUROC 0.795, sensitivity 71.8%, specificity 72.8%, NPV 85.2% and PPV 54.3%) (Figure 1).