Univariate Cox regression analysis was performed on the training cohort, 12 CRLs (NSMCE1-DT, AL161729.4, LINC01138, SEPTIN7-DT, TNFRSF10A-AS1, AC006449.3, AC093382.1, PHC2-AS1, AC099850.3, AC069281.2, ZEB1-AS1, NIFK-AS1) with prognosis value were identified in COAD (Table 1). The gene discussed is NSMCE1; the disease is colon adenocarcinoma.